肩周炎，发病主要原因至今不明，其临床表现为肩部疼痛，夜间更为明显，肩关节活动困难等，常见于五十岁左右的中老年人，因此又名五十肩。据数据统计，肩周炎发病率高达20.6%，虽...[论文全部]

　　the Essential Role of the MeninMLL Complex in Yap1 Transcription and Function . Currently, it is poorly understood whether alterations of active histone modifications, including those of H3K4,are associated with liver tumorigenesis. We furt...[论文全部]

　　79). Nevertheless, the Men1+/- effectively reduced their effect in female mice but not in males (Fig. S4E, lanes 46 and 1012).In addition, administration of DEN significantly increased the menin levels in the livers of C57BL/6 males compare...[论文全部]

　　Menin promotes hepatocellular carcinogenesis andepigenetically up-regulates Yap1 transcription Menin is a scaffold protein encoded by the multiple endocrineneoplasia type 1 (MEN1) gene in humans, and it interacts with a variety of transcrip...[论文全部]

　　Fig. S4. Menin is responsive to chemical carcinogen-induced liver chronic injury and inflammation. (A) The HE staining of the pancreatic islets in Men1WT and Men1+/- mice treated with DEN (25 mg/kg, i.p.) at 15 d of age and euthanized 8 mo...[论文全部]

　　Fig. S1. Menin promotes HepG2 xenograft growth. Independent pair of HepG2 shLuc and shMEN1 cells were s.c. transplanted into nude mice (n = 16 or 17,respectively). The tumor volume (mean SEM) was measured every 2 d at the indicated time poi...[论文全部]

　　Supporting Information Cell Culture and Gene Transfection. The HepG2 (human hepatocellular carcinoma) cell line was obtained from the Type Culture Collection of the Chinese Academy of Sciences. PLC/PRF5 (human hepatoma) and HL-7702 (immorta...[论文全部]

　　无偿献血是指为拯救他人生命，献血者自愿捐献全血、血浆或血液成分，而不收取任何报酬（但在一些情况下会赠送纪念品）的行为。当前已有71个国家和地区血液供应主要来源于无偿献...[论文全部]